ESSM - Exercise science and sports medicine

ASSOC. PROF. MALCOLM COLLINS

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POSITION

Chief Specialist Scientist, South African Medical Research Council
Associate Professor, UCT/MRC Research Unit for Exercise Science and Sports Medicine (ESSM), Department of Human Biology, Faculty of Health Sciences, University of Cape Town

QUALIFICATIONS

PhD (Medical Biochemistry), University of Cape Town (1993)
Thesis title: Characterisation of the Human α2(I) Procollagen Promoter-Binding Proteins
BSc (Hons) (Biochemistry), University of Stellenbosch (1988)
BSc (Biochemistry and Physiology), University of Stellenbosch (1987)

ESSM RESEARCH GROUPS

Injuries and medical conditions associated with sport and exercise
Exercise in the management of chronic diseases
Exercise performance

RESEARCH INTERESTS

Genetic basis of connective tissue overuse injuries
Genetic elements that determine the endurance phenotype and the inter-individual physiological responses during participation in endurance events
Genes associated with obesity

OTHER

B2-rated research scientist, National Research Foundation, South Africa
Medical Biological Scientist in the category Medical Biochemistry with the Health Professionals Council of South Africa

CONTACT

Tel: +27 21 650 4574

Email: Malcolm.Collins@uct.ac.za

PUBLICATIONS

1. Posthumus, M., September, A.V., Keegan, M., O’Cuinneagain, D., van der Merwe, W., Schwellnus, M.P. and Collins M * Genetic Risk Factors for Anterior Cruciate Ligament Ruptures: COL1A1 gene variant. British Journal of Sports Medicine, In Press.

2. Collins, M. *, Mokone, G.G., September, A.V., van der Merve, L. and Schwellnus, M.P. The COL5A1 genotype is associated with range of motion measurements. Scandinavian Journal of Medicine and Science in Sports, In Press.

3. Raleigh, S.M., van der Merve, L, Ribbans, W.J., Smith, R.K.W., Schwellnus, M.P., Collins M. Variants within the MMP3 gene are associated with Achilles tendinopathy: Possible interaction with the COL5A1 gene. British Journal of Sports Medicine, In Press.

4. Harley, Y.X.R, Kohn, T.A., St Clair Gibson, A., Noakes, T.D. and Collins M. Skeletal muscle monocarboxylate transporter content is not different between black and white runners. European Journal of Applied Physiology, In Press.

5. Jennings, C.L., Lambert, E.V., Collins, M, Levitt, N.S. and Goedecke J.H. The atypical presentation of the metabolic syndrome components in black African women: The relationship of insulin resistance and the influence of regional adipose tissue distribution. Metabolism, In Press.

6. September, A.V., Cook, J., Handley, C.J., van der Merwe, L., Schwellnus, M.P., and Collins, M. * Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations. British Journal of Sports Medicine, In Press.

7. Posthumus, M, September, A.V., Schwellnus, M.P., and Collins, M. * Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controls. Journal of Science and Medicine in Sport, In Press.

8. Jennings, C., Lambert, E.V., Collins, M., Joffe, Y., Levitt, D. and Goedecke, J. (2008) Determinants of a healthy metabolic phenotype in normal weight and obese black South African women. Obesity, 16:1602-1609.

9. September, A.V., Posthumus, M., van der Merwe, L., Schwellnus, M.P., Noakes, T.D. and Collins, M. * (2008) The COL12A1 and COL14A1 genes and Achilles tendon injuries. International Journal of Sports Medicine, 29:257-263.

10. Ljungqvist, A., Schwellnus, M.P., Bachl, N., Collins, M., Cook, J., Khan, K., Maffulli, N., Pitsiladis, Y., Riley, G., Golspink, G., Venter, D., Derman, W., Engebretsen, L. and Volpi, P. (2008) International Olympic Committee Consensus statement: Molecular Basis of Connective Tissue and Muscle Injuries in Sport. Clinics in Sports Medicine, 27(1):231-239.

11. Schwellnus, M.P., Drew N. and Collins, M. (2008) Muscle Cramping in Athletes - Risk Factors, Clinical Assessment and Management. Clinics in Sports Medicine, 27:183-194.

12. Evans, J., Collins, M., Jennings, C., van der Merwe, L., Soderstrom, I., Olsonn, T., Levitt, D., Lambert, E.V. and Goedecke. J. (2007) IL-18 genotype and serum levels are associated with metabolic risk factors for cardiovascular disease. European Journal of Endocrinology, 157(5):633-640.

13. Schwabe, K., de Villiers, R., Collins, M. and Schwellnus, M.P. (2007) Achilles tendon blood flow changes in response to acute exercise. International SportMed Journal, 8(3):117-140.

14. Saunders, C.J, September, A.V., Xenophontos, S.L., Cariolou, M.A., Anastassiades, L.C., Noakes, T.D. and Collins M. * (2007) No association of the ACTN3 gene R577X polymorphism with endurance performance in Ironman Triathlons. Annals of Human Genetics, 71:777-781.

15. Hew-Butler, T., Heath, K., Boulter, J., Collins, M., Tucker, R., Dugas, J., Shave, R., George, K.,

Cable, T., Verbalsi, J. and Noakes, T. (2007) Hypernatremia predicts a delayed recovery after an 89

km ultramarathon. Clinical Journal of Sports Medicine, 17(4):289-296.

16. Hew-Butler, T., Collins, M., Bosch, A., Sharwood, K., Wilson, G., Armstrong, M., Jennings, C.,

Swart, J. and Noakes, T. (2007) Maintenance of plasma volume and serum sodium concentrations

despite bodyweight loss in Ironman Triathletes. Clinical Journal of Sports Medicine, 17(2):116-

122.

17. September, A.V., Schwellnus, M.P. and Collins, M. * (2007) Tendon and ligament injuries: The

genetic component. British Journal of Sports Medicine, 41:241-246. (invited review)

18. Smith, J.A.H., Collins, M., Grobler, L.A., Magee, C.J. and Ojuka, E.O. (2007) Exercise and

CaMK activation both increases the binding of MEF2A to the Glut4 promoter in skeletal muscle in

vivo. American Journal of Physiology. Endocrinology Metabolism, 292:E413-E420.

19. Stein, D.J., Collins, M., Daniels, W., Noakes, T.D., Zigmond, M. (2007) Mind and muscle: the

cognitive-affective neuroscience of exercise. CNS Spectr., 12(1):19-22.

20. Elandaloussi, L.M., Lindt, M., Collins, M. and Smith, P.J. (2006) Analysis of P-glycoprotein

expression in purified parasite plasma membrane and food vacuole from Plasmodium falciparum.

Parasitology Research, 99(6):631-637.

21. Saunders, C.J, de Milander, L., Hew-Butler, T., Xenophontos, S.L., Cariolou, M.A., Anastassiades,

L.C., Noakes, T.D. and Collins M. * (2006) Dipsogenic genes associated with weight changes

during Ironman triathlons. Human Molecular Genetics, 15(20):2980-2987.

22. September, A.V., Mokone, G.G., Schwellnus, M.P. and Collins, M. * (2006) Genetic risk factors

for Achilles tendon injuries. International SportMed Journal, 7(3):201-215. (invited review)

23. Goedecke, J.H., Wake, D.J., Levitt, N.S., Lambert, E.V., Collins, M.R., Morton, N.M., Andrew, R., Seckl, J.R. and Walker, B.R. (2006) Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women. Clinical Endocrinology, 65:81-87.

24. Saunders, C.J, Xenophontos, S.L., Cariolou, M.A., Anastassiades, L.C., Noakes, T.D. and Collins M. * (2006) The bradykinin β₂ receptor (BDKRB2) and endothelial oxide synthase 3 (NOS3) genes and endurance performance during Ironman triathlons. Human Molecular Genetics, 15(6):979-987.

25. Hew-Butler, T.D., Sharwood, K., Collins, M., Speedy, D. and Noakes, T. (2006) Sodium supplementation is not required to maintain serum sodium concentrations in athletes during an Ironman triathlon. British Journal of Sports Medicine, 40:255-259.

26. West S.J., Goedecke J.H., van Niekerk L., Collins M, St Clair Gibson A., Macdonald I.A., Noakes T.D. and Lambert E.V. (2006) Effects of evaluated plasma adrenaline levels on substrate metabolism, effort perception and muscle activation during low-to-moderate intensity exercise. Pflugers Archives, 451:727-737.

27. Mokone, G.G., Schwellnus, M.P., Noakes, T.D. and Collins, M. * (2006) The COL5A1 gene and Achilles tendon pathology. Scandinavian Journal of Medicine and Science in Sports, 16:19-26.

28. Walpole, B., Noakes, T.D. and Collins, M. * (2006) The growth hormone 1 (GH1) gene, performance and post-race rectal temperature during the South African Ironman Triathlon. British Journal of Sports Medicine, 40:145-150.

29. St Clair Gibson A., Grobler L.A., Collins M., Lambert M.I., Sharwood K., Derman E.W. and Noakes T.D. (2006) Evaluation of maximal exercise performance, fatigue and depression in athletes with acquired chronic training intolerance. Clinical Journal of Sports Medicine, 16, 39-45.

30. Mokone, G.G., Gajjar, M., September, A.V., Schwellnus, M.P., Greenberg, J., Noakes, T.D. and Collins, M. * (2005) The GT Dinucleotide Repeat Polymorphism within the Tenascin-C Gene is Associated with Achilles Tendon Pathology. American Journal of Sports Medicine, 33, 1016-1020.

31. Rae, D.E., Bosch, A.N., Collins, M. and Lambert, M.I. (2005) The Interaction of Aging and 10 Years of Racing on Ultra-Endurance Running Performance. Journal of Aging and Physical Activity, 13, 210-222.

32. Grobler, L., Collins, M., Lambert, M., Sinclair-Smith, C., Derman, E.W., Noakes, T.D. and St Clair Gibson, A. (2004) Skeletal muscle pathology in endurance athletes with acquired training intolerance. British Journal of Sports Medicine, 38, 697-703.

33. Sharwood, K.A., Collins, M., Goedecke, J., Wilson, G. and Noakes, T.D. (2004) Weight changes, medical complications and performance during an Ironman triathlon. British Journal of Sports Medicine, 38, 718-724.

34. Hudson, D.E., Mokone, G.G., Noakes, T.D. and Collins, M. (2004) The –55 C/T polymorphism within the UCP3 gene and performance during the South African Ironman Triathlon. International Journal of Sports Medicine, 25, 427-432.

35. Robson-Ansley, P.J., de Milander, L., Collins, M. and Noakes, T.D. (2004) Acute interleukin-6 administration impairs athletic performance in healthy, trained male runners. Canadian Journal of Applied Physiology, 29, 411-418.

36. Collins, M. *, Xenophontos, S.L., Cariolou, M.A., Mokone, G.G., Hudson, D.E., Anastasiades, L. and Noakes, T.D. (2004) The ACE gene and endurance performance during the South African Ironman Triathlons. Medicine and Science in Sport and Exercise, 36, 1314-1320.

37. Noakes, T.D., Sharwood, K., Collins, M. and Perkins, D.R. (2004) The dipsomania of great distance: Water intoxication in an Ironman triathlete. British Journal of Sports Medicine, 38, e16.URL:http://www.bjsportmed.com/

38. Grobler, L., Collins, M. and Lambert, M. (2004) Remodelling of Skeletal Muscle following Exercise-Induced Muscle Damage. International SportMed Journal, 5, 67-83.URL:http://www.ismj.com

39. Collins, M. *, Renault, V., Grobler, L.A., St Clair Gibson, A., Lambert, M.I., Derman, E.W., Butler-Browne, G.S., Noakes, T.D. and Mouly, V. (2003) Athletes with exercise-associated fatigue have abnormally short muscle DNA telomeres. Medicine and Science in Sport and Exercise, 35, 1524-1528.

40. Sharwood, K., Collins, M., Goedecke, J., Wilson, G., Noakes, T. and ESSM Ironman research team. (2002) Weight Changes, sodium levels and performance in the South African Ironman Triathlon. Clinical Journal of Sports Medicine, 12, 391-399.

41. Speedy, D., Thompson, J.M.D., Rogers, I., Collins, M., Sharwood, K. and Noakes T.D. (2002) Oral salt supplementation during ultra-distance exercise. Clinical Journal of Sports Medicine, 12, 279-284.

42. Hunter, A.M., St Clair Gibson, A., Collins, M., Wilson, G., Lambert, M.I. and Noakes, T.D. (2002) Caffeine alters neither performance nor pacing strategies during a 100-km cycling time trial performance. International Journal of Sport Nutrition and Exercise Metabolism, 12, 438-452.

43. St Clair Gibson, A., Lambert, M.I., Collins, M., Grobler, L., Sharwood, K.A., Derman, W.E., and Noakes, T.D. (July 2000) Chronic Exercise Activity and the Fatigued Athlete Myopathic Syndrome (FAMS). International SportMed Journal 1(3). URL:http://www.esportmed.com/ismj/

44. Goedecke, J.H., St Clair Gibson, A., Grobler, L., Collins, M., Noakes, T.D., and Lambert, E.V. (2000) Determinants of the Variability in Respiratory Exchange Ratio at Rest and During Exercise in Trained Athletes. American Journal of Physiology. Endocrinology Metabolism, 27, E1325-E1334.

45. Collins, M., Rojnuckarin, P., Zhu, Y-H., and Bornstein, P. (1998) A Far Upstream, Cell-Type-Specific Enhancer of the Mouse Thrombospondin 3 Gene is Located within Intron 6 of the Adjacent Metaxin Gene. Journal of Biological Chemistry, 273, 21816-21824.

46. Collins, M., Smith, A.A. and Parker, M.I. (1998) Characterization of Two Distinct Families of Transcription Factors which bind to the CCAAT Box Region of the Human COL1A2 Gene. Journal of Cellular Biochemistry, 70, 455-467.

47. Collins, M., Leaner, V.D., Madikizela, M. and Parker, M.I. (1997) Regulation of the Human α2(I) Procollagen Gene by Sequences Adjacent to the CCAAT Box. Biochemical Journal, 322, 199-206.

48. Collins, M. and Bornstein, P. (1996) Sp1-Binding Elements, within the Common Metaxin-Thrombospondin 3 Intergenic Region, Participate in the Regulation of the Metaxin Gene. Nucleic Acids Research, 24, 3661-3669.

49. Parker, M.I., Smith, A.A., Mundell, K., Collins, M., Boast, S. and Ramirez, F. (1992) The Abolition of Collagen Gene Expression in SV40-Transformed Fibroblasts is Associated with Trans-acting Factor Switching. Nucleic Acids Research, 20, 5825-5830.